The absence of an identifiable emotional or physical trigger at the initial presentation of Takotsubo syndrome was associated with more than a 15-fold increased odds of recurrence.
Does the absence of an identifiable trigger increase recurrence in patients with Takotsubo syndrome?
Trigger-negative Takotsubo syndrome represents a distinct phenotype with a significantly higher risk of recurrence, highlighting the need for individualized risk stratification beyond the traditional stress-centered paradigm.
Effect estimate: OR >15
assessments, longer follow-up, and evaluations will be required to validate and further refine these findings. ConclusionsThis study provides important insights the recurrence of TTS and highlights the heterogeneity of this disorder.The of trigger-negative TTS as a phenotype prone to recurrence supports a shift from a stress-only paradigm toward a more nuanced, phenotype-oriented understanding of the syndrome.Although many questions remain unanswered, this study represents a meaningful step toward improving individual risk stratification and the long-term management of patients with TTS.
Nakamura et al. (Fri,) conducted a editorial in Takotsubo syndrome (n=236). Trigger-negative Takotsubo syndrome (absence of identifiable trigger) vs. Trigger-positive Takotsubo syndrome was evaluated on Recurrence of Takotsubo syndrome (OR >15). The absence of an identifiable emotional or physical trigger at the initial presentation of Takotsubo syndrome was associated with more than a 15-fold increased odds of recurrence.