What question did this study set out to answer?

To assess the effectiveness of a new diagnostic test for sepsis in improving clinical decision making in the emergency department.

March 30, 2026Open Access

Impact of a Cellular Host-Response Sepsis Diagnostic on Clinical Decision Making in the Emergency Department: A Vignette-Based Study

Key Points

To assess the effectiveness of a new diagnostic test for sepsis in improving clinical decision making in the emergency department.
Conducted a vignette-based, randomized study
Involved emergency department clinicians
Evaluated the impact on decision making and risk stratification
The diagnostic test improved clinicians' decision making for sepsis diagnosis
Enhanced risk stratification among emergency department patients
Demonstrated increased accuracy in sepsis detection when used by clinicians

Abstract

Objectives: Sepsis is a complex pathogen-host interaction that traditional laboratories do not easily detect.A test that rapidly assesses immune dysregulation could improve early diagnosis and clinical decision making.This study evaluates ease of application of a new host-response sepsis diagnostic test (IntelliSep; Cytovale, Inc) and its ability to affect decision making, risk stratification, and diagnostic efficacy in the emergency department (ED).Methods: This was a case vignette-based, randomized, multisite decision-impact study.We conducted the study with ED clinicians from 3 health care institutions,

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Cite This Study

Sheybani et al. (Sat,) studied this question.

synapsesocial.com/papers/69ca12d4883daed6ee095115 https://doi.org/https://doi.org/10.1016/j.acepjo.2026.100358

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