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CXCR4+ cells in NPC tumor sphere have metastatic potential | Synapse

March 30, 2026Open Access

CXCR4+ cells in NPC tumor sphere have metastatic potential

Key Points

To investigate the metastatic potential of CXCR4+ cancer stem cells in nasopharyngeal carcinoma (NPC).
Identified subpopulations of CXCR4+ cells in NPC tumor spheres.
Analyzed the expression of epithelial-mesenchymal transition (EMT) markers.
Evaluated the SDF-1/CXCR4 signaling pathway's role in metastasis.
CXCR4+ CSCs demonstrate pronounced metastatic capability.
Activation of EMT in CXCR4+ cells correlates with increased metastatic potential.
Identifying CXCR4 as a viable biomarker and potential therapeutic target.

Abstract

A metastatic CSC subpopulation present in NPC express CXCR4 and have activated EMT and SDF-1/CXCR4-driven metastasis. CXCR4 may have utility as a biomarker and the SDF-1/CXCR4 axis may be a therapeutic target for NPC.

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Cite This Study

Zhu et al. (Fri,) studied this question.

synapsesocial.com/papers/69ca134b883daed6ee095317 https://doi.org/https://doi.org/10.1016/j.bjorl.2026.101799