Towards precision antibiotic therapy: predictors and outcomes of meropenem target attainment

Key Points

• The aim is to evaluate predictors of meropenem target attainment and the associated outcomes for antibiotic therapy.
• Measured target attainment rates of meropenem in various dosing scenarios.
• Evaluated pharmacokinetic/pharmacodynamic (PK/PD) thresholds for efficacy.
• Analyzed the impact of therapeutic drug monitoring on target achievement.
• Three-quarters of the measurements met the PK/PD target of 100% fT>MIC.
• Half of the measurements achieved the stricter target of 100% fT>4×MIC.
• Personalized dosing strategies are recommended to enhance target attainment rates.