Tildrakizumab, an anti-IL-23p19 antibody, is registered for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy. Its effectiveness in specific patient subgroups—e.g. those with high body weight, high disease burden, involvement of high-impact areas or older patients—is often underrepresented in randomised clinical trials and better captured in real-world settings. To address this gap, the present meta-analysis was undertaken to synthesise data from four observational studies conducted in Germany (TILOT, TiGER, TIL-SENIOR, TIL-TWO), each focusing on distinct psoriasis populations. This meta-analysis of four prospective multicentre non-interventional studies evaluated the effectiveness and safety of tildrakizumab in different patient populations with moderate-to-severe plaque psoriasis. Outcome parameters assessed at baseline, week 16 and 28 included absolute Psoriasis Area Severity Index (PASI) values, proportion of patients with PASI < 1, < 3, < 5, PASI 75, PASI 90 and PASI 100, body surface area (BSA), Physician’s Global Assessment (PGA) 0/1 and Dermatology Life Quality Index (DLQI) 0/1. The meta-analysis was conducted using a random effects model. The meta-analysis included 1504 patients. The course of the absolute PASI and BSA and the proportion of patients achieving PASI < 3, PASI 75, 90, 100, PGA 0/1 and DLQI 0/1 at week 28 was comparable across all four studies. Overall, mean PASI scores decreased from 16.5 (95% confidence intervals (CI) 15.8–17.3) at baseline to 2.8 (95% CI 2.5–3.0) at week 28. The proportion of patients with PGA 0/1 and DLQI 0/1 increased from 1.8% and 3.7% at baseline to 63.5% and 51.2% at week 28, respectively. No new safety signals were identified. Tildrakizumab showed consistent effectiveness across different study populations. Substantial effectiveness was achieved over 28 weeks. Safety results were comparable across populations, without outliers in older patients or patients with higher disease burden. Graphical abstract available for this article. Psoriasis is a common chronic systemic inflammatory disease. It has a substantial impact on patients’ quality of life. Biological compounds such as tildrakizumab have become important treatment options in moderate-to-severe psoriasis. Once a medication is approved, it is important to understand how well a drug works in different types of patients, for example, in the older population, in people with higher body weight, people with psoriasis in sensitive areas such as the scalp and those suffering from particularly severe disease. To explore this, four observational studies were conducted including these patient groups. In the present analysis, we explored whether the effect of tildrakizumab was comparable between the different studies. In total, the four studies included 1504 patients. The results showed that tildrakizumab improved disease severity, reduced the size of affected skin areas and enhanced quality of life across all groups. These improvements were seen over a period of 28 weeks, and safety results were in line with previous studies. Overall, the findings suggest that tildrakizumab can be beneficial for a wide range of patients with psoriasis, regardless of age, body weight or psoriasis severity.
Tsianakas et al. (Sat,) studied this question.