What question did this study set out to answer?

This research aims to expand the understanding of transfusion-related alpha-gal syndrome (TRAGS) by identifying cases and evaluating demographic patterns.

March 30, 2026Open Access

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Transfusion‐related alpha‐gal syndrome: Two new cases expanding the demographic and geographic spectrum, and evidence of a diagnostic gap in allergic transfusion reaction evaluation

MFMackenzie FosterVanderbilt University Medical Center MBMiriam BrownVanderbilt University Medical Center AMAngela MuellerVanderbilt University Medical Center

Key Points

This research aims to expand the understanding of transfusion-related alpha-gal syndrome (TRAGS) by identifying cases and evaluating demographic patterns.
Documented two new cases of TRAGS in the southeastern United States.
Assessed the demographic and geographic spread of TRAGS within qualifying patients.
Examined the role of IgA deficiency and alpha-gal sensitization in transfusion reactions.
TRAGS was found across a broader demographic range than previously recognized.
IgA deficiency was present in 18% of qualifying patients, despite its low prevalence in the general population.
No patients were investigated for alpha-gal sensitization, which is common in this region.

Abstract

TRAGS occurs in the tick-endemic southeastern United States across a broader demographic range than previously recognized. IgA deficiency, present in <0.3% of the population, was considered in 18% of qualifying patients while alpha-gal sensitization, affecting 20%-30% in this region, was investigated in none. Integration of AGS history into pre-transfusion risk assessment and ATR evaluation protocols is warranted.

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Cite This Study

Foster et al. (Sat,) studied this question.

synapsesocial.com/papers/69ca1369883daed6ee095548 https://doi.org/https://doi.org/10.1111/trf.70196

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