Transfusion‐related alpha‐gal syndrome: Two new cases expanding the demographic and geographic spectrum, and evidence of a diagnostic gap in allergic transfusion reaction evaluation

Key Points

• This research aims to expand the understanding of transfusion-related alpha-gal syndrome (TRAGS) by identifying cases and evaluating demographic patterns.
• Documented two new cases of TRAGS in the southeastern United States.
• Assessed the demographic and geographic spread of TRAGS within qualifying patients.
• Examined the role of IgA deficiency and alpha-gal sensitization in transfusion reactions.
• TRAGS was found across a broader demographic range than previously recognized.
• IgA deficiency was present in 18% of qualifying patients, despite its low prevalence in the general population.
• No patients were investigated for alpha-gal sensitization, which is common in this region.