What question did this study set out to answer?

The aim is to establish a framework for risk-based decision-making in managing adult atrial septal defects (ASDs).

April 1, 2026Expert Review of Cardiovascular Therapy0 citations

Optimal treatment choices for adult atrial septal defects: the role of appropriate risk stratification

ÜSÜmit Yaşar Si̇nan NGNeziha Aybüke Geylan ASArzu Bakimci Simsek

Key Result

Personalized risk stratification integrating age, arrhythmias, right ventricular remodeling, and comorbidities should guide adult atrial septal defect management rather than universal closure.

Key Points

The aim is to establish a framework for risk-based decision-making in managing adult atrial septal defects (ASDs).
Review existing evidence on adult ASD management.
Integrate various risk factors such as age and comorbidities.
Develop a decision-oriented framework for treatment.
Risk-based strategies improve management of adult ASDs.
Personalized treatment pathways are more effective than uniform approaches.
Integration of multiple factors leads to better patient outcomes.

Structured PICO

Population

Adults with atrial septal defects (ASD)

Intervention

Risk-based decision-making and personalized treatment pathways

Adult ASD management should transition from universal closure to personalized, risk-stratified treatment pathways within specialized adult congenital heart disease programs.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Risk-based decision-making should be central to adult ASD management, integrating age, atrial arrhythmia burden, right ventricular (RV) remodeling, pulmonary vascular disease, and comorbidities This review translates existing evidence into a practical decision-oriented framework. Future strategies should move away from a 'one-size-fits-all' closure approach toward personalized treatment pathways within specialized adult congenital heart disease (ACHD) programs.

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