Deletion of Lymphatic PD‐L1 Protects Mice From Severe Autoimmune Encephalitis

Key Points

• The research aims to explore the role of lymphatic PD-L1 in autoimmune encephalitis and its effects on disease severity.
• Investigated lymphatic PD-L1 expression in cribriform plate and cervical lymph nodes
• Deleted PD-L1 from lymphatic endothelial cells in a mouse model
• Monitored disease symptoms and brain infiltrate of T cells
• Deletion of lymphatic PD-L1 significantly reduced autoimmune encephalitis symptoms
• Increased brain infiltration of regulatory CD8+ Foxp3+ T cells observed after deletion
• Findings suggest lymphatic PD-L1 plays a critical role in disease progression

Abstract