Cyclic treatment with WIN 18,446 is as efficacious as continuous treatment in suppressing spermatogenesis in mice, potentially allowing faster recovery and reducing testicular injury.
Does cyclic treatment with WIN 18,446 suppress spermatogenesis as effectively as continuous treatment in mice?
Cyclic administration of the ALDH1A inhibitor WIN 18,446 is as effective as continuous dosing for suppressing spermatogenesis in mice, potentially offering a safer profile with faster recovery.
Absolute Event Rate: 0% vs 0%
Cyclic treatment of mice with the ALDH1A inhibitor WIN 18,446 is as efficacious as continuous treatment in suppressing spermatogenesis and may allow for faster recovery of spermatogenesis after the cessation of drug treatment, and reduce the chance of injury to the testes from continuous treatment.
Paik et al. (Sun,) reported a other. Cyclic treatment with WIN 18,446 is as efficacious as continuous treatment in suppressing spermatogenesis in mice, potentially allowing faster recovery and reducing testicular injury.