An infection and pathogenesis mouse model of SARS‐CoV‐2‐related pangolin coronavirus GXP2V (short₃UTR)

Key Points

• To develop a mouse model for studying the pathogenesis and infection effects of the SARS-CoV-2-related pangolin coronavirus GX_P2V.
• Developed a human ACE2-transgenic mouse model
• Evaluated pathogenicity of GX_P2V (short 3' UTR)
• Assessed mortality rates under controlled infection conditions
• GX_P2V caused mortality in the humanized mouse model
• The model demonstrated potential for evaluating vaccine efficacy
• The pangolin coronavirus is identified as highly attenuated