What question did this study set out to answer?

This research aims to investigate the expression of LMP-1 in nasopharyngeal carcinoma and its clinical implications.

April 1, 2026Open Access

Epstein–Barr virus latent membrane protein-1 expression in nasopharyngeal carcinoma with clinical correlation. A study in North East India

NYNito YepthomiChristian Institute of Health Sciences and Research Hospital MLMejungsangla LongkumerChristian Institute of Health Sciences and Research Hospital KKKhrutsozo KikhiChristian Institute of Health Sciences and Research Hospital

Key Points

This research aims to investigate the expression of LMP-1 in nasopharyngeal carcinoma and its clinical implications.
Analyzed LMP-1 expression using immunohistochemistry in nasopharyngeal carcinoma tissues.
Focused on non-keratinizing histological subtype in a North East India cohort.
Assessed correlation with clinical stages of the carcinoma.
A significant number of NPC cases showed positive LMP-1 expression.
High LMP-1 expression was associated with locally advanced disease stages.
The method provides a practical approach for EBV detection in tissue biopsies, especially in resource-limited areas.

Abstract

A significant proportion of NPC, particularly non-keratinizing histological subtype, positive for LMP-1 by immunohistochemistry were locally advanced. This method may serve as a practical approach for detecting EBV infection in tissue biopsies, particularly in resource-limited settings.

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