Gut Microbiome Signatures Differ in Cirrhosis With and Without Hepatocellular Carcinoma in a Southeast Asian Cohort

Key Points

• This study aims to compare gut microbiome signatures between cirrhosis patients with and without hepatocellular carcinoma (HCC).
• Analyzed gut microbiome in a Thai cohort of patients with cirrhosis and HCC
• Measured BCoAT expression levels
• Assessed gut permeability and cytokine profiles
• Patients with HCC showed distinct gut microbial changes compared to those without
• Reduced BCoAT expression was linked with HCC presence
• Increased gut permeability and cytokine alterations were observed in HCC patients