This research aims to develop a method for site-selective phenylselenylation of tryptophan in peptides.
Conducted phenylselenylation of C2 site of indole ring in tryptophan residues.
Utilized an acidic aqueous medium without metal catalysts.
Applied the method to various peptide structures.
Successfully modified the C2 site of the indole ring in tryptophan.
Achieved site selectivity in the presence of various peptides.
Demonstrated the reaction was effective without the use of metal catalysts.
Abstract
A novel site-selective phenylselenylation of C2 site of indole ring in the Trp side chain of various peptides was achieved in an acidic aqueous medium without metal catalysts via an...