Herein, a photocatalytic strategy for the synthesis of gem-difluoroalkenes by the multicomponent cascade reaction of α-trifluoromethyl alkenes with alkenes and TMSN3 is described. This operationally simple protocol provides a powerful strategy to introduce azido fragments into gem-difluoroalkenes, enriching the current library of gem-difluoroalkenes for drug discovery. A gram-scale synthesis and synthetic applications demonstrate the potential application of this methodology in the synthesis of diverse medicinally relevant compounds.
Shen et al. (Mon,) studied this question.
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