Women reported more residual angina at one year post-PCI than men (SAQ score 94.4 vs 96.1), despite having more focal disease and higher post-PCI FFR (0.88 vs 0.87).
Does female sex influence the frequency of residual angina at one year after percutaneous coronary intervention in patients with hemodynamically significant CAD?
Women experience more residual angina than men one year after PCI, despite having more focal CAD patterns and achieving better post-PCI physiological results.
Absolute Event Rate: 0% vs 0%
Abstract Background Significant differences in the presentation of coronary artery disease (CAD) have been observed between women and men. The pullback pressure gradient (PPG) quantifies pathophysiological CAD patterns as focal or diffuse. Objectives This study investigated the influence of sex on residual angina stratified by PPG after percutaneous coronary intervention (PCI). Methods We performed a sub-analysis of the PPG Global, a multicenter, prospective, single-arm study. All patients had hemodynamically significant CAD (fractional flow reserve FFR ≤ 0.80) and underwent a manual FFR pullback to calculate PPG before PCI. Patient-reported outcomes were collected using the 7-item Seattle Angina Questionnaire (SAQ-7) at baseline and one-year follow-up. Results We included 814 patients (205 25.2% women and 609 74.8% men). Women were significantly older than men (70.2±10.2 years vs 67.2±10.0 years p 0.001). Baseline FFR were comparable between sexes (0.68±0.13 vs. 0.66±0.12, p=0.098) but women had a more focal CAD compared to men (PPG 0.66 ± 0.15 vs. 0.63 ± 0.15, p=0.047). Post PCI-FFR was higher in women than men (0.88 ± 0.07 vs. 0.87 ± 0.07, p=0.041); however, angina at one year was more frequent in women (SAQ angina frequency score 94.4 ± 12.4 vs 96.1 ± 9.6, p=0.041). Conclusion Despite having a more focal CAD pattern and achieving higher post-PCI FFR, women report more residual angina than men at one-year follow-up.Graphical abstractFor image description, please refer to the figure legend and surrounding text. SAQ-7 at 12 month - Men vs. WomenFor image description, please refer to the figure legend and surrounding text.
Munhoz et al. (Sun,) reported a other. Women reported more residual angina at one year post-PCI than men (SAQ score 94.4 vs 96.1), despite having more focal disease and higher post-PCI FFR (0.88 vs 0.87).