What question did this study set out to answer?

This research aims to explore the characteristics and treatment outcomes of NK/T-cell malignancies related to Epstein-Barr Virus in Poland.

April 1, 2026

Epstein‐Barr Virus‐positive NK/T‐cell Malignancies in Poland: Distinctive Features, Therapeutic Strategies, and Survival Insights—The Real‐world Retrospective Report of the Polish Lymphoma Research Group

Key Points

This research aims to explore the characteristics and treatment outcomes of NK/T-cell malignancies related to Epstein-Barr Virus in Poland.
Conducted a retrospective analysis of Polish patients with NK/T-cell malignancies.
Evaluated demographic and clinical characteristics in comparison to Asian populations.
Assessed treatment regimens, particularly focusing on asparaginase-containing therapies.
Approximately 45% of patients received asparaginase-containing regimens.
The first-line treatment efficacy appeared lower than existing literature reports.
HLH presence was identified as a critical factor associated with poor survival outcomes.

Abstract

The demographic and clinical characteristics of the Polish patient population were similar to those reported in Asian populations. Approximately 45% of patients received asparaginase-containing regimens. The efficacy of first-line regimens seemed to be lower compared to those reported in the literature. The presence of HLH is the most critical factor predicting poor survival.

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Cite This Study

Filonenko et al. (Sun,) studied this question.

synapsesocial.com/papers/69ccb75916edfba7beb894f2 https://doi.org/https://doi.org/10.1111/ajco.70102

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