Effectiveness of Single‐Wavelength 755 nm Laser Compared to Dual‐Wavelength 755 nm and 1064 nm Laser in Hair Removal: A Split‐Body Design With Blinding

ABSTRACT Introduction Laser hair removal (LHR) has become a popular cosmetic procedure for long‐term hair reduction, with various laser wavelengths and technologies available. Objective This study aimed to compare the safety and effectiveness of single‐wavelength 755 nm laser compared to dual‐wavelength 755 nm and 1064 nm laser in hair removal. Methods Twenty Syrian women, aged 20–33, with complete data, underwent three axillae laser hair removal treatments at 4‐week intervals between January 2024 and May 2024. The participants, who had Fitzpatrick skin types II and III, were divided into two groups using a split‐body design with blinding, resulting in a total of 40 axillae treated. They were treated with the Duetto MT laser system, which utilizes Alexandrite and Nd: YAG lasers emitting at 755 nm and 1064 nm, individually or in combination, and equipped with a 14 mm Spot Handpiece. Efficacy was assessed using standardized photographs, hair counts, and the Global Aesthetic Improvement Scale (GAIS). Pain was evaluated using a Visual Analog Scale (VAS), and safety outcomes were recorded. Results A superior outcome was recorded for a single‐wavelength laser, which showed an overall hair reduction of 92% compared to the dual‐wavelength laser an overall reduction of 69%. Hair counting showed a 25% greater hair reduction with a single wavelength. No severe adverse effects were observed or reported for both groups. Conclusion For skin types II and III, the 755 nm laser is more effective for axillary hair removal than the dual‐wavelength laser, even 12 months after treatment. The procedure is considered safe. In contrast, dual‐wavelength laser therapy offered no extra benefits and caused slightly more adverse effects.