Two infants with human parechovirus-3 infection and systemic inflammatory response syndrome exhibited markedly elevated serum levels of multiple cytokines, particularly MCP-1, IL-6, IL-10, and TNF-α.
Case Report (n=2)
No
Elevated serum levels of multiple inflammatory cytokines in infants with HPeV-3 infection provide direct evidence for the involvement of cytokine storm in its pathophysiology.
SUMMARY Severe outcomes such as sepsis-like illness, meningoencephalitis, and hemophagocytic lymphohistiocytosis have been reported in neonates and young infants with human parechovirus-3（HPeV-3） infection, suggesting a possible significant role for cytokine storm in this infection. However, this remains unproven. In this report, we describe the inflammatory cytokine profiles in serum samples of 2 infants with HPeV-3 infection with systemic inflammatory response syndrome that were investigated using cytokine multiplex assay. Both infants had elevated serum levels of several cytokines, particularly MCP-1, IL-6, IL-10, and TNF-α. These results could provide direct evidence for the involvement of cytokine storm in the pathophysiology of HPeV-3 infection.
Sugiura et al. (Thu,) conducted a case report in Human parechovirus-3 (HPeV-3) infection with pediatric systemic inflammatory response syndrome (n=2). Two infants with human parechovirus-3 infection and systemic inflammatory response syndrome exhibited markedly elevated serum levels of multiple cytokines, particularly MCP-1, IL-6, IL-10, and TNF-α.