Lewis Acid-Promoted Annulation of Electron-Deficient Indoles toward Indoloindoles and Higher Fused Architectures

Key Points

• The objective is to develop a Lewis acid-catalyzed method for synthesizing indole-fused heteroacenes from electrophilic reagents.
• Utilized Lewis acid catalysis for heteroannulation.
• Combined electrophilic indoles and anilines as reactants.
• Conducted DFT studies to analyze reaction mechanisms.
• The method shows a broad substrate scope.
• Demonstrated scalability for practical applications.
• Indicated successful formation of indole-fused compounds.