What question did this study set out to answer?

Investigate the involvement of ferroptosis-related genes in the development of hypoplastic left heart syndrome.

April 1, 2026Open Access

From Limited Samples to Mechanistic Insights: Exploring Ferroptosis-Related Genes in Hypoplastic Left Heart Syndrome

YPYiheng PangGuangxi Medical University NCNaixia Chao HLHongji LiGuangxi Medical University

Key Points

Investigate the involvement of ferroptosis-related genes in the development of hypoplastic left heart syndrome.
Analysis of ferroptosis-related gene expression in hypoplastic left heart syndrome samples
Comparative studies against control gene profiles
Bioinformatics approaches to highlight significant genetic pathways
Identification of key ferroptosis-related genes associated with hypoplastic left heart syndrome
Evidence suggesting a mechanistic link between ferroptosis and HLHS development
Potential biomarkers for further research into congenital heart disease

Abstract

Background: Hypoplastic left heart syndrome (HLHS) is a congenital heart disease (CHD), and accumulating evidence has implicated ferroptosis in the pathogenesis of HLHS. Therefore, exploring ferroptosis-related genes (FRGs) i... | Find, read and cite all the research you need on Tech Science Press

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