What question did this study set out to answer?

This analysis aims to compare outcomes between very young children and older patients with intermediate risk rhabdomyosarcoma treated on the ARST1431 protocol.

April 1, 2026Pediatric Blood & Cancer0 citations

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Intermediate Risk Rhabdomyosarcoma in Very Young Children (Less Than or Equal to 24 months) Treated on the Prior Children's Oncology Group Protocol ARST1431

KWKatrina Winsnes JBJulie A. Bradley ZGZhengya Gao

Key Points

This analysis aims to compare outcomes between very young children and older patients with intermediate risk rhabdomyosarcoma treated on the ARST1431 protocol.
Summary of demographic and tumor characteristics using frequencies and percentages.
Analysis of local failure (LF) frequency by age group, radiation therapy (RT), and delayed primary excision (DPE) status.
Estimation of event-free survival (EFS) and overall survival (OS) using Kaplan–Meier method and log-rank test.
Of 296 patients, 48 (16.2%) were younger than 24 months, with specific age distributions noted.
DPE was performed more frequently in younger patients, indicating potential differences in surgical interventions.
Local failure was found to be lower in those who received DPE in combination with RT compared to those with RT alone.

Abstract

ABSTRACT Background Rhabdomyosarcoma is the most common soft tissue sarcoma in pediatrics and infants are reported to have inferior outcomes. ARST1431 recommended delayed primary excision (DPE) while discouraging radiation (RT) deviations. This analysis compared outcomes among very young and older patients in this study. Procedures Demographic and tumor characteristics were summarized using frequencies and percentages. Local failure (LF) frequency was summarized by age group, RT, and DPE status. Event‐free survival (EFS) and overall survival (OS) were estimated using the Kaplan–Meier method and compared between age groups using the log‐rank test. Results Of 296 patients, 48 (16.2%) were 24 months, respectively. LF in DPE+RT was 8.3% and 6.1%, 24 months old, respectively. Conclusions Outcomes in younger children are comparable to older children with local failure more common in those without DPE. Optimization of local control will be important for future studies. Trial Registration Number NCT02567435

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Cite This Study

Winsnes et al. (Tue,) studied this question.

synapsesocial.com/papers/69cd7b345652765b073a91b5 https://doi.org/https://doi.org/10.1002/1545-5017.70293

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