Correlation of 24-Hour Monitoring of Arterial Pressure with the Inotropic Response of Isolated Myocardial Trabeculas to β-Adrenergic Stimulation in Resistant Arterial Hypertension Combined with Obstructive Coronary Atherosclerosis

A sample of 17 patients with resistant arterial hypertension combined with obstructive coronary atherosclerosis who had indications for coronary bypass surgery was examined. As part of a laboratory and instrumental examination, the patients underwent 24-h blood pressure monitoring in a hospital setting. The reaction of isolated myocardial trabeculae isolated from intraoperative biopsies taken during coronary bypass surgery to the action of β-adrenergic receptor agonists (β-AR) was studied. The association of 24-h blood pressure monitoring with the force of the overall inotropic response of myocardial trabeculae to β-AR stimulation was assessed. It was shown that isolated myocardial trabeculae of patients with average daily systolic blood pressure 130 mmHg. The force of the overall inotropic response of the trabeculae to β-AR stimulation has an inverse correlation with systolic and diastolic pressure. Significant correlations (p < 0.05) were found in the average daily, average night-time, and average day-time formats of blood pressure assessment. It is suggested that the observed lack of differences between the daytime and nighttime periods is due to a more pronounced state of hyperexcitation of the autonomic nervous system in patients with resistant hypertension combined with obstructive coronary atherosclerosis.