Spiropenicitrinol A (1), an intriguing 5/5/6/5 spirocyclic polyketide architecture with a unique 3H-spirobenzo[1,2-b:4,5-b'difuran-2,1'-cyclopentane] core, was obtained from Penicillium citrinum Y12. The structure was established by spectroscopic analysis, quantum-chemical calculations, and single-crystal X-ray crystallography. 1 showed potent anti-inflammatory activity by inhibiting LPS-induced NO, TNF-α, IL-6, and IL-1β production in RAW264.7 cells. These findings indicated that this complex spirocyclic architecture could serve as a promising scaffold for the further development of novel anti-inflammatory agents.
Liu et al. (Tue,) studied this question.
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