Functional Variants of the RAD51 Gene Contribute to Susceptibility to Non‐Syndromic Orofacial Clefts in a Han Chinese Population

Key Points

• The research aims to explore the role of RAD51 gene variants in the susceptibility to non-syndromic orofacial clefts.
• Identified RAD51 variants rs45507396 and rs1801320
• Analyzed genetic data from Han Chinese individuals
• Compared variant frequencies between orofacial cleft cases and controls
• Variants rs45507396 and rs1801320 are significantly associated with non-syndromic orofacial clefts
• Findings provide new genetic insight into cleft susceptibility
• Establishes a theoretical basis for further molecular research