Integrative Multi‐Omics Mendelian Randomization Highlights Causal Autophagy‐Related Genes for Amyotrophic Lateral Sclerosis

Key Points

• To explore causal relationships between autophagy-related genes and amyotrophic lateral sclerosis (ALS) risk.
• Conducted a multi-omics mendelian randomization (MR) analysis.
• Evaluated regulation of four specific autophagy-related genes.
• Analysed data to uncover associations with ALS risk.
• Identified significant causal associations between autophagy genes and ALS risk.
• Provided evidence suggesting the role of autophagy in ALS mechanisms.
• Highlighted potential therapeutic targets for ALS interventions.