Synthesis of planar chiral biferrocenes by iridium-catalyzed 2+2+2 cycloadition of a biferrocene-linked diyne with nitriles: asymmetric desymmetrization and kinetic resolution

Key Points

• The central aim is to develop an efficient synthesis method for planar chiral biferrocenes using iridium catalysis.
• Utilized iridium-catalyzed asymmetric [2+2+2] cycloaddition
• Employed biferrocene-linked diynes as starting materials
• Incorporated nitriles into the cycloaddition process
• Focused on achieving kinetic resolution and asymmetric desymmetrization
• Successfully synthesized a range of planar chiral biferrocenes
• Demonstrated high enantiomeric excess in the products
• Achieved effective resolution of the chiral products