Oligodendrocyte Precursor Cells Shape Retinogeniculate Refinement Via a CHD8-Dependent Phagocytic Pathway

Key Points

• To explore how oligodendrocyte precursor cells (OPCs) influence visual development through phagocytosis and CHD8 regulation.
• Examined the role of OPCs in synapse clearance during visual development around eye opening.
• Analyzed gene expression changes related to phagocytosis driven by CHD8.
• Investigated the dysregulation of the phagocytic pathway in the context of autism.
• Phagocytosis by OPCs was identified as essential for synapse refinement during visual development.
• CHD8 was found to upregulate genes associated with phagocytosis in OPCs.
• Dysregulated phagocytosis pathways were linked to characteristics of autism.