What question did this study set out to answer?

To generate induced pluripotent stem cell lines from a frontotemporal dementia patient with a specific MAPT mutation.

April 3, 2026Stem Cell Research0 citationsOpen Access

Generation of three hiPSC clones from a frontotemporal dementia (FTD) patient with a heterozygous MAPT mutation p. K298H299insQ (c. 896₈97insACA)

THTakumi Hirose KIKei-ichi Ishikawa YLY. Li

Key Points

To generate induced pluripotent stem cell lines from a frontotemporal dementia patient with a specific MAPT mutation.
Isolated cells from a frontotemporal dementia patient with a MAPT mutation.
Established induced pluripotent stem cell lines (iPSCs) from patient cells.
Characterized iPSCs for pluripotency and differentiation potential.
Generated iPSCs showed classic characteristics of pluripotency.
iPSCs demonstrated the ability to differentiate into the three germ layers.
iPSCs maintained stable karyotypes throughout culture.

Abstract

A previously reported microtubule-associated protein tau (MAPT) mutation, p. K298H299insQ, involving a glutamine insertion between lysine 298 and histidine 299, was identified in patients with frontotemporal dementia. We established induced pluripotent stem cell (iPSC) lines from a patient carrying this mutation. Generated iPSCs displayed typical pluripotency characteristics, differentiation potential into three germ layers, and stable karyotypes

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