Engineering Nanosensitizer into Hierarchical Modulators for Sonodynamic Antibacterial Therapy

Key Points

• This research aims to develop a new therapeutic method using sonodynamic therapy to combat antibiotic-resistant bacteria.
• Developed nanosensitizers for improved ultrasound activation.
• Tested the efficacy of these sensitizers against antibiotic-resistant bacteria.
• Evaluated antibacterial effects through in vitro experiments.
• Nanosensitizers significantly increased the antibacterial effects under ultrasound activation.
• Demonstrated enhanced efficacy against multiple drug-resistant bacteria compared to standard treatments.