Design and Synthesis of Thiophene-Based C 2 -Symmetric Chiral Phosphoric Acids on a Decahydroquinoxaline scaffold for Stereoselective Transformations

Key Points

• The aim is to design and synthesize thiophene-based chiral phosphoric acids for use in stereoselective transformations.
• Designed thiophene-based phosphoric acid on a decahydroquinoxaline scaffold.
• Synthesized the catalyst using enantiopure trans-1,2-diaminocyclohexane as a precursor.
• Evaluated the catalyst in various stereoselective reactions.
• The synthesized chiral phosphoric acids demonstrated effective catalytic activity.
• Significant stereoselectivity was observed in the transformations.
• The results suggest a practical application in asymmetric catalysis.