Cooley's Legacy Endures—Elliptocytes in X‐Linked Sideroblastic Anemia due to Aminolevulinate Synthase 2 Mutations

Key Points

• To examine the presence of elliptocytosis in children diagnosed with X-linked sideroblastic anemia and its relation to historical findings.
• Analyzed red cell morphology in three children with XLSA.
• Conducted histograms of red cell band 3 content.
• Compared findings to descriptions of hereditary elliptocytosis.
• All three children exhibited prominent elliptocytosis.
• Red cell band 3 content histograms were similar to those in hereditary elliptocytosis.
• Findings support Cooley's descriptions of elliptocytosis from 1945.