Efficacy and safety of risperidone for attention deficit hyperactivity disorder and disruptive behaviour disorders: a systematic review and meta-analysis

Key Points

• This research examines the effectiveness and safety of risperidone for treating ADHD and associated disruptive behaviour disorders.
• Conducted a systematic review of existing studies on risperidone's impact on ADHD and disruptive behaviour disorders.
• Performed a meta-analysis to quantify treatment effects and safety outcomes.
• Evaluated outcomes such as aggression reduction and side effects like weight gain and metabolic syndrome.
• Risperidone significantly reduces aggression and oppositional behaviors in children with ADHD and disruptive behaviour disorders.
• Associated risks include increased weight gain, elevated serum prolactin levels, and potential metabolic syndrome.
• Findings suggest a balance between therapeutic benefits and safety concerns.