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April 3, 2026Diabetes Obesity and Metabolism0 citations

Efficacy and Safety of Apolipoprotein C‐ III Inhibitors in Hypertriglyceridemia: A Network Meta‐Analysis of Randomised Controlled Trials

MEMohammed A. ElbahloulKafrelsheikh University AGAliaa GamalDeraya University OMOdai MaihoubLatakia University

Key Points

The aim is to assess the efficacy and safety of apolipoprotein C-III inhibitors in managing hypertriglyceridemia.
Conducted a network meta-analysis of randomized controlled trials
Collected data on triglyceride levels and other lipid parameters
Evaluated the risk of acute pancreatitis and cardiovascular outcomes
ApoC-III inhibitors significantly improved triglyceride levels
Showed substantial reduction in the risk of acute pancreatitis
Future trials needed for assessing long-term cardiovascular effects

Abstract

ApoC-III inhibitors significantly improved triglyceride levels and other lipid parameters and, most importantly, substantially reduced the risk of acute pancreatitis. Future trials are needed to evaluate their effects on cardiovascular outcomes.

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Cite This Study

Elbahloul et al. (Tue,) studied this question.

synapsesocial.com/papers/69cf5ebd5a333a821460d504 https://doi.org/https://doi.org/10.1111/dom.70717

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