Palladium-Catalyzed Defluorinative Coupling of Indoles with α,α-Difluoro-β,γ-Unsaturated Ketones: Direct Access to Functionalized α-Fluoroenones

Key Points

• This research aims to develop a method for synthesizing α-fluoroenones from indoles and difluoro-unsaturated ketones.
• Utilized palladium as a catalyst for the coupling process.
• Combined indoles with α,α-difluoro-β,γ-unsaturated ketones.
• Conducted reactions under mild conditions for improved yields.
• Achieved moderate to excellent yields of (Z)-α-fluoroenones.
• Generated a diverse range of functionalized compounds.