The aim is to evaluate long-term outcomes of children with chronic active Epstein-Barr virus infection after managing infected lymphocyte subpopulations.
Profiled EBV-infected lymphocytes to guide treatment
Managed lymphocyte subpopulations for prolonged control
Utilized prompt hematopoietic cell transplantation (HCT) when necessary
Prolonged control of chronic active Epstein-Barr virus achieved without HCT in some cases
CD4+ T-cell involvement necessitates timely HCT to avoid disease progression
Delayed interventions lead to risk of transformation of the infection
Abstract
EBV-infected lymphocyte profiling guided prolonged HCT-free control of CAEBV. CD4+T-cell CAEBV requires a prompt rather than elective HCT to prevent progression and transformation.