フェロトーシス誘導を介した抗がん活性を有する山菜由来のエンドパーオキサイド化合物

Key Points

• The study aims to evaluate the anticancer effects of endoperoxide compounds derived from wild vegetables through ferroptosis induction.
• Examined the role of glutathione and various proteins in ferroptosis.
• Assessed reactive oxygen species (ROS) levels.
• Investigated the activation of ferroptosis suppressor protein 1 and glutathione peroxidase.
• Endoperoxide compounds effectively induced ferroptosis in cancer cells.
• Increased levels of reactive oxygen species were observed.
• Inhibition of glutathione peroxidase activity was noted, enhancing ferroptosis.