OX40L in endothelial cells promotes temporomandibular joint subchondral bone angiogenesis and osteoclastogenesis in mice

Key Points

• The study investigates the role of endothelial OX40L in promoting angiogenesis and osteoclastogenesis in temporomandibular joint osteoarthritis.
• Analyzed endothelial cell signaling pathways in mouse models
• Assessed angiogenesis in subchondral bone
• Evaluated osteoclastogenesis mechanisms
• Endothelial OX40L significantly increases subchondral bone angiogenesis
• Promotion of osteoclastogenesis was observed alongside increased angiogenesis
• Findings highlight the pathological role of OX40L in TMJOA development