What question did this study set out to answer?

To understand the implications of a negative trial regarding bronchiolitis obliterans syndrome following lung transplantation.

April 4, 2026European Respiratory Journal0 citations

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What can we learn from a negative randomised controlled trial in bronchiolitis obliterans syndrome after lung transplantation?

OBOlivier Brugière BGBerta Sáez Giménez

Key Points

To understand the implications of a negative trial regarding bronchiolitis obliterans syndrome following lung transplantation.
Conducted a randomised controlled trial
Assessed the outcomes related to bronchiolitis obliterans syndrome
Defined chronic lung allograft dysfunction for functional analysis
Approximately 80% of chronic lung allograft dysfunction cases were associated with bronchiolitis obliterans syndrome
Negative trial results indicate limited effectiveness of the tested intervention
Findings emphasize the need for improved strategies in managing bronchiolitis obliterans syndrome

Abstract

Extract Lung transplantation (LTx) is now a widely accepted procedure for end-stage pulmonary diseases. Nevertheless, long-term survival after LTx remains limited because of chronic lung allograft dysfunction (CLAD), which is mainly manifested as bronchiolitis obliterans syndrome (BOS), accounting for approximately 80% of CLAD cases 1. The definition of BOS was first introduced in 1993 by an ad hoc working group of the International Society of Heart and Lung Transplantation (ISHLT), with the aim of developing a clinically applicable and standardised method for assessing functional results after LTx 2.

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Cite This Study

Brugière et al. (Wed,) studied this question.

synapsesocial.com/papers/69d0adc2659487ece0fa4415 https://doi.org/https://doi.org/10.1183/13993003.02412-2025

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