Time-associated phenotypic changes related to virulence and immune interaction of Staphylococcus aureus during relapsing infection within individual hosts

Key Points

• This research aims to explore the dynamic phenotypic changes of Staphylococcus aureus associated with relapsing infections in individual hosts.
• Isolates of S. aureus were recovered sequentially from individual patients.
• Phenotypic characteristics were assessed over time during relapsing infections.
• Time-associated variations were documented and analyzed.
• Sequential isolates displayed coordinated phenotypic changes over time.
• Time-related differences may influence the virulence of S. aureus during infections.
• Findings highlight the complex interactions between S. aureus and the host immune response.