What question did this study set out to answer?

This research aims to uncover how L. johnsonii helps protect against intestinal inflammation caused by ETEC.

April 4, 2026Open Access

Limosilactobacillus johnsonii alleviates intestinal inflammation by metabolically reprogramming macrophages through modulation of arginine metabolism and glycolytic pathways

Key Points

This research aims to uncover how L. johnsonii helps protect against intestinal inflammation caused by ETEC.
Used 4-week-old male C57BL/6 mice model
Administered L. johnsonii to assess macrophage metabolic changes
Analyzed arginine metabolism and glycolytic pathways in macrophages
L. johnsonii reduced inflammation markers in the intestines of mice
Macrophage function was significantly altered by L. johnsonii administration
Changes in arginine metabolism and glycolysis were observed in macrophages after treatment

Abstract

Enterotoxigenic Escherichia coli (ETEC) is a major diarrheal pathogen in humans and animals, causing intestinal barrier dysfunction and inflammatory bowel diseases.Limosilactobacillus johnsonii (L.johnsonii), a well-characterized probiotic, has been shown to alleviate diarrheal diseases by modulating macrophage function.This study aimed to elucidate the molecular mechanisms by which L. johnsonii confers protection against ETEC-induced intestinal injury.Eighteen 4-week-old male C57BL/6 mice

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Cite This Study

Ge et al. (Thu,) studied this question.

synapsesocial.com/papers/69d0ae68659487ece0fa463c https://doi.org/https://doi.org/10.1017/anr.2026.10038

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