What question did this study set out to answer?

The aim is to achieve harmonization of IGF1 immunoassays using a higher-order LC-MS/MS reference.

April 4, 2026Open Access

Harmonization of IGF1 immunoassays toward a higher-order LC-MS/MS reference anchor

ELEgwm LentjesUtrecht University MPM.S PrattUniversity Medical Center Groningen IKIP KemaUniversity Medical Center Groningen

Key Points

The aim is to achieve harmonization of IGF1 immunoassays using a higher-order LC-MS/MS reference.
Utilized matrix-matched serum reference materials (RMs) for value assignment.
Applied a higher-order LC-MS/MS analytical procedure for consistency.
Focused on reducing bias and variability among different immunoassays.
Significant reduction in inter-assay bias was observed.
Variability among IGF1 immunoassays decreased substantially.
A robust foundation for cross-platform interpretation was established.

Abstract

Matrix-matched, commutable serum RMs value-assigned by a higher-order LC-MS/MS procedure enable substantial reduction of inter-assay bias and variability among IGF1 immunoassays. Harmonization toward a higher-order analytical anchor is achievable in routine practice and provides a robust foundation for consistent cross-platform interpretation.

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