Phage-display immunoprecipitation sequencing reveals distinct antibody signatures against bacterial flagellins associated with treatment response in Crohn's disease

Key Points

• The research aims to identify antibody signatures associated with treatment response in Crohn's disease using sequencing techniques.
• Conducted phage-display immunoprecipitation sequencing (PhIP-Seq)
• Analyzed antibody responses against bacterial flagellins
• Assessed associations with treatment outcomes in Crohn's disease patients
• Biologic treatment response was linked to decreased antibody responses to specific bacterial flagellins
• Identified conserved sequences in bacterial flagellins associated with treatment response
• Findings suggest potential biomarkers for improving treatment outcomes