Exploring an azo-uracil based nickel( ii ) complex for anticancer and phosphatase like activities

Key Points

• The research aims to evaluate the anticancer and phosphatase-like activities of an azo-uracil based nickel(II) complex.
• Synthesize azo-uracil based Ni(II) complex N1
• Test cytotoxicity against murine and human colorectal cancer cell lines
• Assess binding affinity to calf thymus DNA
• Examine phosphatase-like activity in vitro
• N1 complex exhibits significant cytotoxicity toward colon carcinoma cells but spares normal fibroblast cells.
• Binding to ct-DNA is confirmed, indicating potential interaction with genetic material.
• Demonstrates phosphatase-like activity, suggesting catalytic potential.