Intra-abdominal adhesions are a common postoperative complication, often resulting in pain, infertility, or bowel obstruction. Despite various preventive measures, effective and safe treatment options remain limited. Recently, interest has grown in plant-derived agents with anti-inflammatory and antifibrotic properties. Lavandula angustifolia (LA) and Helichrysum arenarium (HA) oils are two such candidates, but their effects on adhesion formation have not been directly compared. This study aimed to evaluate and compare the impact of intraperitoneally administered LA and HA oils on adhesion development in a rat model using macroscopic, histopathological, and immunohistochemical methods. Intra-abdominal adhesions were induced using the ischemic button model, followed by intraperitoneal administration of sterile saline (control), LA (75 mg/kg), and HA (1500 mg/kg). On postoperative day 14, the animals were euthanized, and macroscopic adhesion scoring, histopathological evaluation, Picro-Sirius Red staining, and measurements of TGF-α, VEGF-α, TNF-α, and Caspase-3 levels were conducted. Macroscopic scores did not differ significantly among the groups (P=0.363). Fibrosis and inflammation scores were significantly higher in the HA group (P
Yalçın et al. (Thu,) studied this question.