A novel derivative from carotene-type sesquiterpene, (1S,2R,3aR,6S,8aS)-1-isopropyl-3a,6-dimethyldecahydroazulene-1,2,6-triol (1), was successfully isolated from filamentous fungus Trichoderma virens NBRC 31959. The structure and molecular formula of 1 were determined by interpretation of 1D and 2D NMR and HRMS data. The absolute configuration was established unambiguously by single-crystal X-ray diffraction, with the Flack parameter supporting the assignment. This study adds to the chemical diversity of sesquiterpene-type CAF603 derivatives of Trichoderma virens.
Aziz et al. (Thu,) studied this question.