Ferulic acid, a derivative of hydroxycinnamic acid, is a potent antioxidant used in dermatology for its ability to neutralize reactive oxygen species and stabilize vitamins C and E. Its multidirectional action includes photoprotection, anti-inflammatory effects, and inhibition of melanogenesis. The study aimed to quantitatively evaluate the impact of 20% ferulic acid peels on skin barrier function, sebum level, pH, and biomechanical properties (elasticity). A group of 18 subjects underwent a series of three treatments. Objective skin parameters were measured. Assessments were conducted at baseline and 14 days post-treatment. A statistically significant increase in stratum corneum hydration was observed on the cheek. Barrier function improved significantly, with transepidermal water loss (TEWL) decreasing in both analyzed areas. Biomechanical analysis revealed a statistically significant improvement in elasticity (R2 parameter) on the cheek and forehead (p < 0.05). Ferulic acid has the potential to improve epidermal hydration and support the skin’s permeability barrier, as evidenced by reduced TEWL. The stability of skin pH suggests high tolerability, confirming ferulic acid as an effective therapeutic agent for mature and sensitive skin.
Wacewicz-Muczyńska et al. (Wed,) studied this question.