Transcriptional signatures and topological reorganization of morphometric similarity networks in temporal lobe epilepsy with unilateral hippocampal sclerosis

Key Points

• The study investigates how transcriptional changes and network topology relate to cortical alterations in temporal lobe epilepsy with unilateral hippocampal sclerosis.
• Analyzed morphometric similarity networks to understand cortical reorganization patterns.
• Examined transcriptomic profiles to assess RNA-metabolism interplay in the context of temporal lobe epilepsy.
• Identified patient-specific patterns for lateralization based on network topology.
• Demonstrated significant network reorganization in patients with unilateral hippocampal sclerosis.
• Found RNA-metabolic interactions that may contribute to cortical vulnerability in temporal lobe epilepsy.
• Established a link between macroscale connectomic changes and microscale transcriptomic profiles.