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This research explores how low-salt diets affect claudin-3 expression and sodium handling in the kidneys.

April 5, 2026Acta Physiologica0 citationsOpen Access

Low‐Salt Diet Induces Claudin‐3 Expression and Drives Adaptive Changes in Collecting Duct of Claudin‐3‐Deficient Mice

ASAli SassiUniversity of Geneva ACAlexandra ChassotUniversity of Geneva SJSara JellaliUniversity of Geneva

Key Points

This research explores how low-salt diets affect claudin-3 expression and sodium handling in the kidneys.
Investigated the role of aldosterone in claudin-3 expression
Analyzed paracellular sodium barrier integrity in collecting ducts
Compared sodium transport in claudin-3-deficient mice under low-salt conditions
Aldosterone was found to increase claudin-3 expression.
Compensatory changes in other claudins and sodium transporters were observed in the absence of claudin-3.
Sodium homeostasis was maintained through adaptive mechanisms despite low-salt conditions.

Abstract

Our findings demonstrate that aldosterone strengthens the paracellular sodium barrier in the collecting duct by inducing claudin-3. In the absence of claudin-3, compensatory regulation of other claudins and sodium transporters preserves sodium homeostasis under low-salt conditions, thus revealing adaptive mechanisms in renal sodium handling.

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