Abstract Background Diminished levels of FXIII are significantly correlated with hematoma expansion (HE) and unfavorable clinical outcomes. Although the crucial function of FXIII in coagulation is well-recognized, the connection between FXIII deficiency and either HE or negative prognosis in patients with spontaneous intracerebral hemorrhage (sICH) is not well understood. Methods Patients with sICH were confirmed through baseline computed tomography scans conducted within 6 h of symptom onset. Plasma FXIII levels were assessed at the time of admission using a standardized enzyme-linked immunosorbent assay. Restricted cubic spline models were employed to explore potential nonlinear relationships between admission FXIII levels and both hematoma expansion and clinical outcomes. Multivariable logistic regression analyses were performed to ascertain the association between FXIII levels and functional outcomes at 3 months postonset. Results In the study cohort of 132 patients with sICH, 49 experienced HE. The median admission level of FXIII was significantly lower in patients with HE, with a median IQR of 8.21 mg/L (6.33, 10.37), compared with those without HE, who had a median value IQR of 11.68 mg/L (8.49, 21.20), p 3, by a factor of 59.45 (OR 59.45, 95% CI 7.258–487.006; p < 0.001), and increased the risk of mortality by a factor of 12.07 (OR 12.07, 95% CI 2.526–57.669; p = 0.002) in patients with sICH. Conclusions In a prospective observational cohort study of patients with sICH, FXIII deficiency was found to be associated with HE and poor prognosis.
Wang et al. (Fri,) studied this question.