Response to Kawamoto et al

Key Points

• The aim is to address concerns about the reproducibility and methodological rigor in the study of senolytic activity.
• Critically review the methodologies used in the original study.
• Evaluate the evidence supporting the claims of senolytic activity.
• Suggest improvements for future studies in this field.
• Identified gaps in methodology impacting reproducibility.
• Highlighted the need for clearer experimental protocols.
• Encouraged more detailed reporting of results and analysis.